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Posted by Alex Jordan

Is the HPV vaccine safe? Understanding the side effects

a doctor with an iPad showing a girl the details on the iPad
Medically reviewed by Dr. James Ryan
4 minute read

Human Papillomavirus (HPV) is a common virus that can lead to serious health issues, like cervical cancer. The HPV vaccine helps prevent these diseases, but many worry about its safety and side effects. This article looks at the safety, benefits, and side effects of the HPV vaccine, focusing on women's health. 

Importance of the HPV vaccine 

The HPV vaccine is crucial in preventing HPV-related cancers. The Centers for Disease Control and Prevention (CDC) says it can prevent over 90% of cancers caused by HPV. This includes cervical, vaginal, and vulvar cancers in women [1]. Getting vaccinated before being exposed to the virus offers the best protection. 

Safety of the HPV vaccine 

Extensive safety monitoring 

Since its licensure in 2006, over 270 million doses of HPV vaccines have been distributed worldwide. Safety monitoring by organizations like the World Health Organization (WHO) and the CDC has found no new adverse events of concern. The most common reactions are mild and include pain at the injection site, swelling, and redness. Serious side effects are rare and include fainting and, very rarely, anaphylaxis (a severe allergic reaction) [2][3][6]. 

Studies and findings 

Numerous large-scale studies have confirmed the safety of the HPV vaccine. For instance: 

  • The WHO's Global Advisory Committee on Vaccine Safety reviewed data from countries like Denmark, the UK, and the US, finding no significant increased risk for conditions like Guillain-Barré syndrome (GBS) [2]. 
  • The CDC has conducted multiple studies showing no confirmed safety signals other than fainting, which can occur with any vaccination [3]. 
  • A study by the National Cancer Institute (NCI) highlighted that despite increasing parental concerns, there is no evidence linking the HPV vaccine to serious health issues like infertility or autoimmune diseases [4]. 

Pregnancy and the HPV vaccine 

Research has also focused on the safety of the HPV vaccine during pregnancy. Studies have shown that inadvertent vaccination during pregnancy does not significantly increase the risk of miscarriage or other adverse pregnancy outcomes [3][7]. 

Common HPV vaccine side effects 

Like all vaccines, the HPV vaccine can cause side effects. These are usually mild and go away on their own. Common side effects include: 

  • Pain, redness, or swelling at the injection site 
  • Headache 
  • Fatigue 
  • Nausea 
  • Dizziness and fainting, particularly among teenagers 
  • Mild fever 
  • Muscle or joint pain [5][6] 

These side effects show that the body is building protection against HPV. Many people who get the HPV vaccine have no side effects at all. These side effects are generally mild and short-lived. 

Rare side effects 

Rarely, serious side effects can happen. These include: 

  • Allergic reactions: Severe allergic reactions are very rare. Symptoms may include trouble breathing, swelling of the face and throat, and a fast heartbeat [5][7]. 
  • Fainting: Fainting can happen, especially in teenagers. This is not unique to the HPV vaccine and can happen after any vaccine. It’s a good idea to sit or lie down for about 15 minutes after getting the shot to avoid fainting [6]. 

Long-term safety considerations 

No long-term side effects 

Extensive research and monitoring have shown that the HPV vaccine is safe in the long term. Studies have followed vaccinated people for over ten years, and the data consistently show no major long-term health risks. Claims that the HPV vaccine causes conditions such as chronic fatigue syndrome, infertility, or premature ovarian failure have been thoroughly investigated and debunked. These conditions occur naturally and their incidence has not increased beyond expected rates in the absence of vaccination [3][5][7]. 

Safety monitoring 

The HPV vaccine has been administered to millions of people worldwide, with robust safety monitoring systems in place. Reports of serious health issues following vaccination are extremely rare and typically not causally linked to the vaccine. Health authorities continuously review safety data [6]. 

Why the HPV vaccine is recommended for women 

The HPV vaccine is very important for women because it lowers the risk of cervical cancer, one of the most common cancers in women. By preventing HPV infections, the vaccine also reduces the risk of other cancers and genital warts. Vaccinating women helps control the spread of HPV, improving public health [8]. 

Vaccination guidelines and recommendations 

The HPV vaccine is usually recommended for preteens, but it can be given as early as age nine. It works best when given before any exposure to HPV, which is why it is recommended for young adolescents. For those who miss the vaccine in early adolescence, catch-up vaccination is recommended up to age 26 [3][9]. 

Why is the HPV vaccine not recommended after 26 years of age? 

After age 26, people are more likely to have been exposed to HPV, making the vaccine less effective. However, those aged 27 to 45 can still get the vaccine after talking with their doctor to check their risk and benefits [8][9]. 

How can side effects of the HPV vaccine be managed? 

Managing side effects of the HPV vaccine is simple: 

  • Pain and swelling: Apply a cool, damp cloth to the injection site to reduce pain and swelling [3][7]. 
  • Fever: Drink plenty of fluids and rest. Over-the-counter fever reducers can help if needed [5]. 
  • Fainting: Sit or lie down for 15 minutes after getting the vaccine to prevent falls [6]. 
  • Allergic reactions: If a severe allergic reaction happens, get medical help right away [3][7]. 

The HPV vaccine is a safe and effective way to prevent HPV-related diseases, including cervical cancer. While common side effects are usually mild and go away quickly, rare side effects do happen but are very uncommon. Long-term studies support the vaccine's safety, making it vital for women's health. Vaccinating young women not only protects them but also helps public health efforts [1][8]. 

How HealthHero can help 

HealthHero provides detailed information and support on the HPV vaccine and other health topics. Our experts are here to answer your questions and guide you through your healthcare needs. For more information on the HPV vaccine and its benefits, visit our HPV Vaccine page. 

Sources

  1. Centers for Disease Control and Prevention (CDC). https://www.cdc.gov/vaccinesafety/vaccines/hpv-vaccine.html [Date accessed July 22, 2024]
  2. World Health Organization (WHO)

    . https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/human-papillomavirus-vaccines/safety [Date accessed July 22, 2024]
  3. European Centre for Disease Prevention and Control (ECDC). https://www.ecdc.europa.eu/en/publications-data/hpv-vaccine-safe [Date accessed July 22, 2024]
  4. National Cancer Institute (NCI)

    . https://www.cancer.gov/news-events/cancer-currents-blog/2021/hpv-vaccine-parents-safety-concerns [Date accessed July 22, 2024]
  5. NHS. https://www.nhs.uk/vaccinations/hpv-vaccine/ [Date accessed July 22, 2024]
  6. HSE.ie. https://www.hse.ie/eng/health/immunisation/hcpinfo/schoolproghcp/hpvsafety/ [Date accessed July 22, 2024]
  7. HSE.ie. https://www.hse.ie/eng/health/immunisation/hcpinfo/othervaccines/hpvadults/ [Date accessed July 22, 2024]
  8. HSE.ie. https://www.hse.ie/eng/health/immunisation/pubinfo/schoolprog/hpv/hpv-vaccination-programme/ [Date accessed July 22, 2024]